Article

Regulatory features aid interpretation of 3’UTR Variants

2023-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Our ability to determine the clinical impact of variants in 3’ untranslated regions (UTRs) of genes remains poor. We provide a thorough analysis of 3’UTR variants from several datasets. Variants in putative regulatory elements including RNA-binding protein motifs, eCLIP peaks, and microRNA sites are up to 16 times more likely than other variants to have gene expression and phenotype associations...

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Literature Corpus work: f5ee4578-ef9f-511e-867b-1a898fde7565
DOI: 10.1101/2023.08.01.551549

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