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Article

Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

1 Dec 2020

Abstract excerpt

Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2. On the basis of our previously identified humanized cross-neutralizing antibody H014, we systematically analyzed a fully human naive antibody library and rationally...

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Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 33262452
DOI: 10.1038/s41422-020-00444-y

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