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Article

Superimmunity by pan-sarbecovirus nanobodies

1 Jun 2022

Abstract excerpt

Vaccine boosters and infection can facilitate the development of SARS-CoV-2 antibodies with improved potency and breadth. Here, we observe superimmunity in a camelid extensively immunized with the SARS-CoV-2 receptor-binding domain (RBD). We rapidly isolate a large repertoire of specific ultra-high-affinity nanobodies that bind strongly to all known sarbecovirus clades using integrative proteomics. These...

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PMID: 35738279
DOI: 10.1016/j.celrep.2022.111004

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