Article

Optimizing a Human Monoclonal Antibody for Better Neutralization of SARS-CoV-2

2024-12-05

Abstract excerpt

SARS-CoV-2 has largely evolved to resist antibody pressure, with each successive viral variant becoming more and more resistant to serum antibodies in the population. This evolution renders all previously authorized anti-spike therapeutic monoclonal antibodies inactive, and it threatens the remaining pipelines against COVID-19. We report herein the isolation of a human monoclonal antibody with a broad but incomple...

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Literature Corpus work: bf2807f7-96cb-53d8-9448-6b63b7fe343f
DOI: 10.1101/2024.12.04.626800

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