Article

GLUT1 inhibition blocks growth of RB1-positive Triple Negative Breast Cancer

2019-09-11

Abstract excerpt

Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expression of glucose transporter 1 (GLUT1, encoded by SLC2A1 ) and associated metabolic dependencies in TNBC, we investigated the vulnerability of TNBC cell lines and pati...

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Literature Corpus work: 850497d6-cf97-552b-b678-a6a1126838bc
DOI: 10.1101/764944

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