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TBC1 domain-containing proteins are frequently involved in triple-negative breast cancers in connection with the induction of a glycolytic phenotype.

Cell death & disease - 4 Sept 2024

Lupi Mariadomenica, Avanzato Daniele, Confalonieri Stefano, Martino Flavia, Pennisi Rosa, Pupo Emanuela, Audrito Valentina, Freddi Stefano, Bertalot Giovanni, Montani Francesca, Matoskova Bronislava, Sigismund Sara, Di Fiore Pier Paolo, Lanzetti Letizia

Abstract excerpt

Metabolic plasticity is a hallmark of cancer, and metabolic alterations represent a promising therapeutic target. Since cellular metabolism is controlled by membrane traffic at multiple levels, we investigated the involvement of TBC1 domain-containing proteins (TBC1Ds) in the regulation of cancer metabolism. These proteins are characterized by the presence of a RAB-GAP domain, the TBC1 domain, and typically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39231952
DOI: 10.1038/s41419-024-07037-2
PMCID: PMC11375060

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