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Article

YAP1-TEAD1-Glut1 axis dictates the oncogenic phenotypes of breast cancer cells by modulating glycolysis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Nov 2017

Lin Chunli, Xu Xiaofeng

Abstract excerpt

Altered energy metabolism is a universal property of most cancer cells. The Hippo signaling pathway and its principal downstream effector YAP1 are responsible for tissue homeostasis including organ size, cell proliferation, apoptosis, and differentiation. Dysregulation of the Hippo pathway leads to the activation of YAP1 and further culminates in the development of multiple human cancers. In this study, by...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Glucose Transporter Type 1

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Source

Identifiers

PMID: 28892790
DOI: 10.1016/j.biopha.2017.08.091

Genes

YAP1
TEAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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