Article

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

2019-10-11

Abstract excerpt

Lacking effective targeted therapies, triple-negative breast cancer (TNBCs) is highly aggressive with development of metastasis especially brain, and remains clinically challenging breast cancer subtype to treat. Despite the survival dependency on the proteasome pathway genes, FDA-approved proteasome inhibitors induced minimal clinical response in breast cancer patients due to weak proteasome inhibition. Here, we...

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Literature Corpus work: f224bbc3-a4e5-5526-8dd2-9180ee9e69cc
DOI: 10.1101/801720

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