Article
A Monocyte-Orchestrated IFN-I-to-IL-4 Cytokine Axis Instigates Protumoral Macrophages and Thwarts Poly(I:C) Therapy.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2021
Guo Panpan, Yang Limin, Zhang Mengfan, Zhang Yuyan, Tong Yuanyuan, Cao Yanlan, Liu Jianghuai
Abstract excerpt
Type I IFNs (IFN-I) are important for tumor immune surveillance and contribute to the therapeutic responses for numerous treatment regimens. Nevertheless, certain protumoral activities by IFN-I have been increasingly recognized. Indeed, our recent work showed that systemic poly(I:C)/IFN treatment can undesirably trigger high arginase (ARG1) expression within the tumor-associated monocyte/macrophage compartment....
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