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Article

High-dimensional phenotyping reveals novel macrophage-like and hybrid subsets within murine splenic conventional dendritic cells.

PloS one - 1 Jan 2026

Yang Chunqing, Xue Qingjie, Feng Yu, Ding Wenjun, Lu Ying, Wang Qinqin

Abstract excerpt

Conventional dendritic cells (cDCs) are pivotal antigen-presenting cells (APCs) with critical roles in immune regulation, yet their subset classification remains ambiguous due to phenotypic overlap with macrophages and monocytes, particularly in the spleen. This study employed multi-parametric flow cytometry and clodronate liposome (CL) depletion to systematically re-evaluate splenic CD11chighMHCIIhigh cDCs in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41615933
DOI: 10.1371/journal.pone.0341819
PMCID: PMC12857976

Genes

APC
CCR2
CD4
MERTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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