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Article

Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes.

The Journal of experimental medicine - 7 Sept 2020

Pallett Laura J, Burton Alice R, Amin Oliver E, Rodriguez-Tajes Sergio, Patel Amit A, Zakeri Nekisa, Jeffery-Smith Anna, Swadling Leo, Schmidt Nathalie M, Baiges Anna, Gander Amir, Yu Dominic, Nasralla David, Froghi Farid, Iype Satheesh, Davidson Brian R, Thorburn Douglas, Yona Simon, Forns Xavier, Maini Mala K

Abstract excerpt

The human liver contains specialized subsets of mononuclear phagocytes (MNPs) and T cells, but whether these have definitive features of tissue residence (long-term retention, lack of egress) and/or can be replenished from the circulation remains unclear. Here we addressed these questions using HLA-mismatched liver allografts to discriminate the liver-resident (donor) from the infiltrating (recipient) immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32602903
DOI: 10.1084/jem.20200050
PMCID: PMC7478732

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