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Article

TCF7L2 is a master regulator of muscle wasting in severe cancer cachexia

2022-09-14

Abstract excerpt

<title>Abstract</title> <p>Hyper-activation of the canonical Wnt signalling pathway drives tumour initiation and cancer progression. Of the four TCF/LEF transcription factors that propagate Wnt signalling, TCF7L2 is believed to be relevant in colorectal cancer because it is essential for adult gut homeostasis. However, this has been challenging to verify because <italic>Tcf7l2</italic> germline or adulthood knock...

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Literature Corpus work
84f579d4-6e95-53a5-95a2-a16dc69fe832
DOI
10.21203/rs.3.rs-2033935/v1
Open publication

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TCF7L2 is a master regulator of muscle wasting in severe cancer cachexiaDOI 10.21203/rs.3.rs-2033935/v1
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