Article

The amino acid transporter SLC7A5 drives progression of PI3K-mutant intestinal cancer models and enhances response to MAPK-targeted therapy

2024-09-26

Abstract excerpt

<title>Abstract</title> Colorectal cancer (CRC) is a complex disease with key oncogenic pathways, including Wnt, MAPK, and PI3K, co-operating to drive tumour initiation and progression. Loss-of-function mutations in the Wnt-pathway inhibitor <italic>APC</italic> are the most prominent genetic alterations and are commonly seen as the tumour-initiating event. Here, we have used genetically engineered mouse model...

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Literature Corpus work: cd35c0cf-9646-553b-a888-614141fe3acb
DOI: 10.21203/rs.3.rs-5002395/v1

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The amino acid transporter SLC7A5 drives progression of PI3K-mutant intestinal cancer models and enhances response to MAPK-targeted therapyDOI 10.21203/rs.3.rs-5002395/v1Read

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