Article

Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers

2024-11-25

Abstract excerpt

Hyper-activation of the canonical Wnt signaling pathway drives small intestine and colon tumors. As the major Wnt pathway effector in healthy intestines, TCF7L2 is a suspected oncogene in both cancer types. However, this has been challenging to verify because Tcf7l2 knockout is lethal. To circumvent lethality, we generated a novel transgenic mouse that allows dose-dependent, systemic, inducible and reversible rep...

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Literature Corpus work: 79c6d92f-b9a1-5287-bbbe-52ac9007d2b9
DOI: 10.1101/2024.11.22.624913

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