Article

Ethnicity-specific transcriptomic variation in immune cells and correlation with disease activity in systemic lupus erythematosus

2020-11-17

Abstract excerpt

<title>Abstract</title> <p>Systemic lupus erythematosus (SLE) is an autoimmune disease in which outcomes vary among different racial groups. We leverage cell-sorted RNA-seq data (CD14 + monocytes, B cells, CD4 + T cells, and NK cells) from 120 SLE patients (63 Asian and 57 White individuals) and apply a four-tier approach to identify SLE subgroups within this multiethnic cohort: unsupervised clustering, different...

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Literature Corpus work: 84de3966-6033-5ab5-98e0-134aa8dfbf1c
DOI: 10.21203/rs.3.rs-100876/v1

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