Article

An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity that Reverses Carfentanil-Induced Respiratory Depression

2023-07-04

Abstract excerpt

<h4>ABSTRACT</h4> The opioid overdose crisis primarily driven by potent synthetic opioids resulted in more than 500,000 deaths in the US over the last 20 years. Though naloxone, a short acting medication, remains the primary treatment option for temporarily reversing opioid overdose effects, alternative countermeasures are needed. Monoclonal antibodies present a versatile therapeutic opportunity that can be tailo...

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Literature Corpus work: 84c907a4-889e-591b-acc7-bea4c3a207c9
DOI: 10.1101/2023.07.04.547721

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