Article

Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B

2019-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Botulinum neurotoxin (BoNT) is the most potent natural toxin known. Of the seven BoNT serotypes (A to G), types A, B, E, and F cause human botulism. Treatment of human botulism requires the development of effective toxin-neutralizing antibodies without side effects such as serum sickness and anaphylaxis. In this study, we generated fully human monoclonal antibodies (HuMAbs) against serotype B Bo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c632d05a-a260-586b-9471-62d92ae3b739
DOI: 10.1101/2019.12.18.881920

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype BDOI 10.1101/2019.12.18.881920Read

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum NeurotoxinsSemantic proximity Read

Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and BSemantic proximity Read

Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization.Semantic proximity Read

New Engineered-Chimeric Botulinum Neurotoxin Mutant Acts as an Effective Bivalent Vaccine Against Botulinum Neurotoxin Serotype A and E.Semantic proximity Read

Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells.Semantic proximity Read

Therapeutic Applications of Botulinum Neurotoxins in Veterinary MedicineSemantic proximity Read

Challenges in searching for therapeutics against Botulinum NeurotoxinsSemantic proximity Read

Embracing the Versatility of Botulinum Neurotoxins in Conventional and New Therapeutic ApplicationsSemantic proximity Read

Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodiesSemantic proximity Read

The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A SubtypesSemantic proximity Read

Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxinSemantic proximity Read

De novo subtype and strain identification of botulinum neurotoxin type B through toxin proteomicsSemantic proximity Read