Article

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

2024-04-21

Abstract excerpt

Interstitial cystitis (IC) is a chronic inflammatory bladder disorder with recurring severe pain, lacking timely diagnostic and therapeutic options. Here, we propose a unitary theranostic nanocluster-antibody-drug conjugate (NADC) by covalently placing dihydroorotate dehydrogenase inhibitors (DHODHi) and ultrasmall gold quantum clusters (AuQCs) on a nerve growth factor (NGF) antagonistic antibody with simultaneous...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f33d0cab-5d1f-5b8f-9049-5ce5fd3349db
DOI: 10.1101/2024.04.20.590432

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitisDOI 10.1101/2024.04.20.590432Read

Genetically Engineered Biomimetic Nanozymes Reprogram Immune Niches to Intercept Colitis-Carcinoma TransitionSemantic proximity Read

Advancements in Nanoceria for Immunotherapy ApplicationsSemantic proximity Read

Current and emerging drugs for interstitial cystitis/bladder pain syndrome (IC/BPS).Semantic proximity Read

Targeted Delivery of STING agonist via Albumin Nanoreactor Boosts Immunotherapeutic Efficacy against Aggressive CancersSemantic proximity Read

Disease Landscape-Guided Design of Neutrophil-Specific Reporters for Early and Accurate Pneumonia Detection in Vivo and in UrineSemantic proximity Read

A Comprehensive Review on Therapeutic Potential of NanobodiesSemantic proximity Read

Improved diagnostic identification of urothelial carcinoma through solid-state nanopore determination of urinary hyaluronan size distributionSemantic proximity Read

PD-1/PD-L1 Inhibitor-Related Cystitis: Clinical Features, Diagnostic Exclusion, and Outcomes in an Eight-Patient Case Series with a Targeted Literature ReviewSemantic proximity Read

Microneedles loaded with cerium-manganese oxide nanoparticles for targeting macrophages in the treatment of rheumatoid arthritisSemantic proximity Read

Nanotechnology in urology.Semantic proximity Read

PASTA: Versatile Tyramine-oligonucleotide Amplification for Multi-modal Spatial BiologySemantic proximity Read

Phytocarbon Nanodots Restore Glutathione Homeostasis via γ-Glutamylcysteine Synthetase against Ferroptosis-Driven Renal FibrosisSemantic proximity Read