A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV

Abstract excerpt

Anti-HIV envelope broadly neutralizing antibodies (bnAbs) are alternatives to conventional antiretrovirals with the potential to prevent and treat infection, reduce latent reservoirs, and/or mediate a functional cure. Clinical trials with “first generation” bnAbs used alone or in combination show promising antiviral effects but also highlight that additional engineering of “enhanced” antibodies will be required fo...

Topics

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• Binding Sites, Antibody
• Broadly Neutralizing Antibodies
• CD4 Antigens
• HIV Antibodies
• HIV Research and Treatment
• Immune Cell Function and Interaction
• Monoclonal and Polyclonal Antibodies Research
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

fd8dd656-362d-5c62-a004-e4081f3b25d2

DOI

10.1101/2024.10.14.618178