Article

An Epitope-Focused Trypanosome-Derived Vaccine Platform Elicits High-Affinity Antibodies and Immunity Against Fentanyl Effects

2022-05-02

Abstract excerpt

<h4>Summary</h4> Poorly antigenic small molecules pose challenges for the production of clinically efficacious antibodies. To address this, we have developed an immunization platform derived from the antigenic surface coat of the African trypanosome. Through sortase-based conjugation of antigens to the trypanosome surface coat protein variant surface glycoprotein (VSG), we created the VAST ( V SG-immunogen A rr...

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Literature Corpus work: 80a4ba4b-22fa-5f90-b187-46aa4335219d
DOI: 10.1101/2022.05.02.487070

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