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Article

Electrostatic tuning of cellular excitability.

Biophysical journal - 3 Feb 2010

Börjesson Sara I, Parkkari Teija, Hammarström Sven, Elinder Fredrik

Abstract excerpt

Voltage-gated ion channels regulate the electric activity of excitable tissues, such as the heart and brain. Therefore, treatment for conditions of disturbed excitability is often based on drugs that target ion channels. In this study of a voltage-gated K channel, we propose what we believe to be a novel pharmacological mechanism for how to regulate channel activity. Charged lipophilic substances can tune channel...

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Identifiers

PMID: 20141752
DOI: 10.1016/j.bpj.2009.10.026
PMCID: PMC2814211

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