Article
Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC).
Breast cancer research and treatment - 1 Jun 2011
Campa Daniele, Claus Rainer, Dostal Lucie, Stein Angelika, Chang-Claude Jenny, Meidtner Karina, Boeing Heiner, Olsen Anja, Tjønneland Anne, Overvad Kim, Rodríguez Laudina, Bonet Catalina, Sánchez Maria-José, Amiano Pilar, Huerta José María, Barricarte Aurelio, Khaw Kay-Tee, Wareham Nicholas, Travis Ruth C, Allen Naomi E, Trichopoulou Antonia, Bamia Christina, Benetou Vassiliki, Palli Domenico, Agnoli Claudia, Panico Salvatore, Tumino Rosario, Sacerdote Carlotta, van Kranen Henk, Bas Bueno-de-Mesquita H, Peeters Petra H M, van Gils Carla H, Lenner Per, Sund Malin, Lund Eiliv, Gram Inger Torhild, Rinaldi Sabina, Chajes Veronique, Romieu Isabelle, Engel Pierre, Boutron-Ruault Marie Christine, Clavel-Chapelon Françoise, Siddiq Afshan, Riboli Elio, Canzian Federico, Kaaks Rudolf
Abstract excerpt
AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ratio after ATP depletion. Once activated, AMPK inhibits fatty acid synthesis and the Akt-mTOR pathway, and activates the p53-p21 axis. All these molecular mechanisms are thought to play a key role in breast carcinogenesis. We investigated the genetic variability of...
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