Article
Common Variant in ALDH2 Modifies the Risk of Breast Cancer Among Carriers of the p.K3326* Variant in BRCA2.
JCO precision oncology - 1 Apr 2022
Kluźniak Wojciech, Szymiczek Agata, Rodrigue Amelie, Wokołorczyk Dominika, Rusak Bogna, Stempa Klaudia, Huzarski Tomasz, Gronwald Jacek, Lubiński Jan, Zamani Neda, Zhang Shiyu, Masson Jean-Yves, Narod Steven A, Cybulski Cezary, Akbari Mohammad R
Abstract excerpt
PURPOSE: The BRCA2 p.K3326* variant is considered a low-penetrance variant for breast cancer. Aldehydes that accumulate in cells under insufficient aldehyde oxidation were most recently shown to trigger carcinogenesis by promoting depletion of BRCA2 protein. Allele T of the common variant rs10744777 in the ALDH2 gene was associated with reduced expression of aldehyde dehydrogenase, the main enzyme in aldehyde...
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