Article

Genetic impairment of ketone body signalling is a prevalent contributor to human metabolic dysfunction

2025-10-02

Abstract excerpt

Emerging evidence that circulating levels of key metabolic intermediates are sensed by a range of G-Protein Coupled receptors (GPCRs) is providing critical new insights into the control of systemic metabolic homeostasis, and how disturbances in such sensing may contribute to metabolic disease. The hydroxycarboxylic acid receptors for lactate (HCAR1), β-hydroxybutyrate (HCAR2), and octanoate (HCAR3) are encoded by...

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Literature Corpus work: 235757f4-85ac-5f80-b5fa-0a8ee775d2e8
DOI: 10.1101/2025.09.30.25336995

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