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Article

Distinct mechanisms of DNA repair in mycobacteria and their implications in attenuation of the pathogen growth.

Mechanisms of ageing and development - 1 Apr 2012

Kurthkoti Krishna, Varshney Umesh

Abstract excerpt

About a third of the human population is estimated to be infected with Mycobacterium tuberculosis. Emergence of drug resistant strains and the protracted treatment strategies have compelled the scientific community to identify newer drug targets, and to develop newer vaccines. In the host macrophages, the bacterium survives within an environment rich in reactive nitrogen and oxygen species capable of damaging its...

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PMID: 21982925
DOI: 10.1016/j.mad.2011.09.003

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