Article

Genome-wide analysis and polygenic prediction of clinical obesity and comparison with body mass index

2026-05-22

Abstract excerpt

A new definition of clinical obesity was introduced by the 2025 Lancet Diabetes & Endocrinology Commission to characterize excess body fat and dysfunctional adiposity beyond body mass index (BMI). We performed the first genome-wide analysis (GWAS) of 151,642 cases of clinical obesity and 128,874 controls without obesity from the All of Us Research Program and UK Biobank spanning five ancestry groups and compared t...

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Literature Corpus work: 84b71e92-2a44-5bb4-a0f6-474bee7bd730
DOI: 10.64898/2026.05.20.26353665

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