Article
Genome-wide association study provides novel insight into the genetic architecture of severe obesity.
PLoS genetics - 1 Sept 2025
Krishnan Mohanraj, Anwar Mohammad Yaser, Justice Anne E, Chittoor Geetha, Chen Hung-Hsin, Roshani Rashedeh, Scartozzi Alyssa, Dickerson Rachel R, Smit Roelof A J, Preuss Michael H, Chami Nathalie, Hadad Benjamin S, Parra Esteban J, Cruz Miguel, Hui Qin, Wilson Peter W F, Sun Yan V, Zhang Xiaoyu, Linchangco Gregorio V, Kardia Sharon L R, Faul Jessica D, Weir David R, Bielak Lawrence F, Highland Heather M, Young Kristin L, Qi Baiyu, Wang Yujie, Fornage Myriam, Haiman Christopher, Cheng Iona, Peters Ulrike, Kooperberg Charles, Buyske Steven, McCormick Joseph B, Fisher-Hoch Susan P, Lona-Durazo Frida, Peralta Jesus, Gomez-Zamudio Jamie, Rich Stephen S, Ferrier Kendra R, Lange Ethan M, Gignoux Christopher R, Kenny Eimear E, Wojcik Genevieve L, Cho Kelly, Gaziano Michael J, Djousse Luc, Liu Shuwei, Vaidya Dhananjay, de Mutsert Renée, Josyula Navya S, Bauer Christopher R, Zhao Wei, Walker Ryan W, Smith Jennifer A, Lange Leslie A, Meyer Mariah C, Liu Ching-Ti, Yanek Lisa R, Lee Miryoung, Raffield Laura M, Loos Ruth J F, Gordon-Larsen Penny, Below Jennifer E, North Kari E, Graff Mariaelisa
Abstract excerpt
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limiting knowledge about its mechanisms and impacts. In genome-wide association study (GWAS) meta-analyses of the tail end of the BMI distribution (≥95th percentile BMI) and two...
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