Article
The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.
Frontiers in endocrinology - 1 Jan 2022
Wang Zhe, Choi Shing Wan, Chami Nathalie, Boerwinkle Eric, Fornage Myriam, Redline Susan, Bis Joshua C, Brody Jennifer A, Psaty Bruce M, Kim Wonji, McDonald Merry-Lynn N, Regan Elizabeth A, Silverman Edwin K, Liu Ching-Ti, Vasan Ramachandran S, Kalyani Rita R, Mathias Rasika A, Yanek Lisa R, Arnett Donna K, Justice Anne E, North Kari E, Kaplan Robert, Heckbert Susan R, de Andrade Mariza, Guo Xiuqing, Lange Leslie A, Rich Stephen S, Rotter Jerome I, Ellinor Patrick T, Lubitz Steven A, Blangero John, Shoemaker M Benjamin, Darbar Dawood, Gladwin Mark T, Albert Christine M, Chasman Daniel I, Jackson Rebecca D, Kooperberg Charles, Reiner Alexander P, O'Reilly Paul F, Loos Ruth J F
Abstract excerpt
Polygenic risk scores (PRSs) aggregate the effects of genetic variants across the genome and are used to predict risk of complex diseases, such as obesity. Current PRSs only include common variants (minor allele frequency (MAF) ≥1%), whereas the contribution of rare variants in PRSs to predict disease remains unknown. Here, we examine whether augmenting the standard common variant PRS (PRScommon) with a rare...
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