Article

Variance Decomposition Accesses a Clinically Supported Discovery Space Systematically Missed by Mean-Based Transcriptomic Prioritization

2026-03-30

Abstract excerpt

<title>Abstract</title> <p>Background Computational prioritization of therapeutic antigen candidates relies predominantly on mean-level differential expression (DEG) analysis. Whether this approach systematically excludes a clinically relevant tier of the transcriptome has not been formally tested. Methods We compared genome-wide variance decomposition (TANK) and mean-based ranking across 32 TCGA cancer types (...

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Literature Corpus work: 44a005eb-81d3-5cb8-b252-1a36a1b1eb17
DOI: 10.21203/rs.3.rs-9188519/v1

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