Article

TumorArchetypeR: A modular framework to derive signature-based tumor subtypes

2026-05-14

Abstract excerpt

<h4>Motivation</h4> The tumor microenvironment (TME) dictates cancer progression and therapeutic response, yet translating TME subtypes into robust clinical biomarkers remains a significant challenge. Existing classification models typically rely on static gene signatures and cohort-dependent normalization, making them ill-suited for application to the small, unbalanced datasets common in early-phase clinical tri...

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Literature Corpus work: 94bfbd9c-2edd-5f2e-8da3-83fc6ddaa2e9
DOI: 10.64898/2026.05.11.724259

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