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Article

Variance-based Prioritization Reveals a Clinically Validated Antigen Discovery Space Systematically Inaccessible to Mean-Based Methods

2026-03-26

Abstract excerpt

<title>Abstract</title> <p>Background. Mean-based transcriptomic prioritization (differential expression analysis, DEG) dominates cancer target discovery but is optimized for driver gene identification rather than therapeutic antigen discovery. Whether variance-based prioritization captures a complementary and clinically relevant discovery space has not been systematically evaluated. Methods. We applied varianc...

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Literature Corpus work
96b7a6dd-86ec-5bd9-89aa-cbd8f877c4d4
DOI
10.21203/rs.3.rs-9215598/v1
Open publication

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Variance-based Prioritization Reveals a Clinically Validated Antigen Discovery Space Systematically Inaccessible to Mean-Based MethodsDOI 10.21203/rs.3.rs-9215598/v1
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