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Article

Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease.

Scientific reports - 5 Jan 2016

Zhang Liang, Trushin Sergey, Christensen Trace A, Bachmeier Benjamin V, Gateno Benjamin, Schroeder Andreas, Yao Jia, Itoh Kie, Sesaki Hiromi, Poon Wayne W, Gylys Karen H, Patterson Emily R, Parisi Joseph E, Diaz Brinton Roberta, Salisbury Jeffrey L, Trushina Eugenia

Abstract excerpt

Altered brain metabolism is associated with progression of Alzheimer's Disease (AD). Mitochondria respond to bioenergetic changes by continuous fission and fusion. To account for three dimensional architecture of the brain tissue and organelles, we applied 3-dimensional electron microscopy (3D EM) reconstruction to visualize mitochondrial structure in the brain tissue from patients and mouse models of AD. We...

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Identifiers

PMID: 26729583
DOI: 10.1038/srep18725
PMCID: PMC4700525

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