Article

Mitochondrial Complex I Modulator Restores Network Resilience in Advanced Alzheimer’s Disease Through Metabolic Reprogramming

2026-06-17

Abstract excerpt

Mitochondrial dysfunction and lipid dysregulation are among the earliest abnormalities in Alzheimer’s disease (AD), yet their mechanistic interplay and therapeutic potential remain poorly understood. Here, we investigated whether restoration of mitochondrial function can reverse metabolic dysfunction and promote resilience in advanced-stage AD. Female APP/PS1 mice were treated with the brain-penetrant mitochondria...

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Literature Corpus work: 9c3b235c-ae57-5d4e-ab3c-026f2fee9606
DOI: 10.64898/2026.06.14.732179

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