Article

Presenilin 1 (PS1) located at mitochondrial inner membrane regulates mitochondrial cristae junction proteins arrangement and cristae formation in HEK293 cells

2026-03-08

Abstract excerpt

Presenilin 1 (PS1), a key pathogenic factor in familial Alzheimer’s disease, is implicated in regulation of mitochondrial functions, yet its precise sub-mitochondrial localization and underlying mechanisms remain poorly understood. In this study, we generated PS1 knockout (PS1 KO) cell lines to investigate the role of PS1 in mitochondrial structure and function. Our results demonstrated that PS1 is directly locali...

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Literature Corpus work: b20ec768-8798-5c88-a6d8-071ed00933fb
DOI: 10.64898/2026.03.05.709976

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Presenilin 1 (PS1) located at mitochondrial inner membrane regulates mitochondrial cristae junction proteins arrangement and cristae formation in HEK293 cellsDOI 10.64898/2026.03.05.709976Read

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