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Mitochondrial complex I deficiency induces Alzheimer's disease–like signatures that are reversible by targeted therapy

29 Jul 2025

Abstract excerpt

Abstract INTRODUCTION Mitochondrial dysfunction is implicated in Alzheimer's disease (AD), but whether it drives AD‐associated changes is unclear. We assessed transcriptomic alterations in the brains of Ndufs4 −/− mice, a model of mitochondrial complex I (mtCI) deficiency, and evaluated the therapeutic effects of the neuroprotective mtCI inhibitor CP2. METHODS Cortico‐hippocampal tissue from Ndufs4 −/− and...

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PMID: 40731203
DOI: 10.1002/alz.70519

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