Article

Early Detection of the Pathogenetic Variants of HRR Genes in Prostate Cancer: Critical Analysis and Experimental Design

2024-12-02

Abstract excerpt

It has been shown that the pathogenic variants (PVs) of the DDR genes, whether of a germinal or somatic nature, represent a predictive biomarker of high sensitivity to treatment with inhibitors of the enzyme PARP, in patients with hormone-resistant metastatic prostate cancer (HRPCa). Moreover, the detection of PVs of the HRR genes in PCa patients can help to define the patient’s prognosis and the choice of the the...

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Literature Corpus work: 844fc999-20b2-5226-8c6b-c2ee14c42621
DOI: 10.20944/preprints202412.0042.v1

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