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Real-world data on the prevalence of BRCA1/2 and HRR gene mutations in patients with primary and metastatic castration resistant prostate cancer.

World journal of urology - 22 Aug 2024

Hommerding Moritz, Hommerding Oliver, Bernhardt Marit, Kreft Tobias, Sanders Christine, Tischler Verena, Basitta Patrick, Pelusi Natalie, Wulf Anna-Lena, Ohlmann Carsten-Henning, Ellinger Jörg, Ritter Manuel, Kristiansen Glen

Abstract excerpt

PURPOSE: This study seeks to contribute real-world data on the prevalence of BRCA1/2 and HRR gene mutations in prostate cancer. METHODS: We compiled sequencing data of 197 cases of primary and metastatic prostate cancer, in which HRR mutation analysis was performed upon clinical request within the last 5 years. All cases were analyzed using a targeted NGS BRCAness multigene panel, including 8 HRR genes (ATM,...

Topics

Aged
Aged, 80 and over
Humans
Male
Middle Aged
BRCA1 Protein
BRCA2 Protein
Genes, BRCA1
Genes, BRCA2
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

Prevalence

Prostatic Neoplasms, Castration-Resistant

Source

Open in PubMed Open full text

Identifiers

PMID: 39172235
DOI: 10.1007/s00345-024-05188-7
PMCID: PMC11341621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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