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Real-world data on the prevalence of BRCA1/2 and HRR gene mutations in patients with primary and metastatic castration resistant prostate cancer.

World journal of urology - 22 Aug 2024

Hommerding Moritz, Hommerding Oliver, Bernhardt Marit, Kreft Tobias, Sanders Christine, Tischler Verena, Basitta Patrick, Pelusi Natalie, Wulf Anna-Lena, Ohlmann Carsten-Henning, Ellinger Jörg, Ritter Manuel, Kristiansen Glen

Abstract excerpt

PURPOSE: This study seeks to contribute real-world data on the prevalence of BRCA1/2 and HRR gene mutations in prostate cancer. METHODS: We compiled sequencing data of 197 cases of primary and metastatic prostate cancer, in which HRR mutation analysis was performed upon clinical request within the last 5 years. All cases were analyzed using a targeted NGS BRCAness multigene panel, including 8 HRR genes (ATM,...

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Identifiers

PMID: 39172235
DOI: 10.1007/s00345-024-05188-7
PMCID: PMC11341621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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