Article
Germline Testing for Prostate Cancer Patients: Evidence-Based Evaluation of Genes Recommended by NCCN Guidelines.
The Prostate - 1 Sept 2025
Xu Jianfeng, Lu Jim, Gielzak Marta, Lilly Zheng S, Lu Lucy, Wei Jun, Cornell Brandon, Shi Zhuqing, Wang Qiang, Tran Huy, Engelmann Valentina, Ashworth Annabelle, Lin Kirk, Ross Ashley E, Walsh Patrick C, Marshall Catherine, Luo Jun, Isaacs William B, Helfand Brian T, Pavlovich Christian P
Abstract excerpt
BACKGROUND: Approximately 50% of prostate cancer (PCa) patients meet the National Comprehensive Cancer Network (NCCN) guidelines for germline testing at diagnosis. However, the selection of genes for testing, their supporting evidence, and clinical interpretation remain poorly understood. METHODS: An evidence-based evaluation of the recommended genes was conducted using data from the UK Biobank and Johns Hopkins...
Topics
- Humans
- Male
- Prostatic Neoplasms
- Germ-Line Mutation
- Genetic Testing
- Middle Aged
- Aged
- Genetic Predisposition to Disease
- Practice Guidelines as Topic