Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down-regulation of DLC1 in endothelial cells compromises the angiogenesis process.

Cancer letters - 10 Jul 2017

Shih Yi-Ping, Yuan Sarah Y, Lo Su Hao

Abstract excerpt

DLC1 is a RhoGAP-containing tumor suppressor that inhibits angiogenesis by repressing VEGF production in epithelial cells. Here we report the roles of DLC1 in endothelial cells. Silencing of DLC1 (siDLC1) enhances cell migration but reduces tube formation activities of human umbilical vein endothelial cells (HUVECs). Biochemically, RhoA activity and paxillin protein level are markedly increased in siDLC1 HUVECs....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down-Regulation
Share to Endothelial Cells
Share to GTPase-Activating Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

Share to Neovascularization, Physiologic

Share to Paxillin

Share to rho GTP-Binding Proteins

Share to rhoA GTP-Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 28408355
DOI: 10.1016/j.canlet.2017.04.004
PMCID: PMC5460982

Genes

DLC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulation of DLC1 in endothelial cells compromises the angiogenesis process.PMID 28408355Read ↗

<i>Dlc1</i> controls cardio-vascular development downstream of Vegfa/Kdrl/Nrp1 signaling in the zebrafish embryoSemantic proximity Read ↗

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization.Semantic proximity Read ↗

Endothelial cells require functional FLVCR1a during developmental and adult angiogenesisSemantic proximity Read ↗

FOXF1 Transcription Factor Is Required for Formation of Embryonic Vasculature by Regulating VEGF Signaling in Endothelial CellsSemantic proximity Read ↗

DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.Semantic proximity Read ↗

Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinomaSemantic proximity Read ↗

Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos.Semantic proximity Read ↗

Low-Density Lipoprotein Receptor-Related Protein-1 Signaling in AngiogenesisSemantic proximity Read ↗

Essential role of endothelial Notch1 in angiogenesis.Semantic proximity Read ↗

DLC‐1:a Rho GTPase‐activating protein and tumour suppressorSemantic proximity Read ↗

Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis.Semantic proximity Read ↗

Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.