Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.

Development (Cambridge, England) - 1 Dec 2009

Hogan Benjamin M, Herpers Robert, Witte Merlijn, Heloterä Hanna, Alitalo Kari, Duckers Henricus J, Schulte-Merker Stefan

Abstract excerpt

The development of arteries, veins and lymphatics from pre-existing vessels are intimately linked processes controlled by a number of well-studied reiteratively acting signalling pathways. To delineate the mechanisms governing vessel formation in vivo, we performed a forward genetic screen in zebrafish and isolated the mutant expando. Molecular characterisation revealed a loss-of-function mutation in the highly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Arteries

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Intracellular Signaling Peptides and Proteins

Share to Neovascularization, Physiologic

Share to Vascular Endothelial Growth Factor C

Share to Vascular Endothelial Growth Factor Receptor-3

Share to Zebrafish

Source

Identifiers

PMID: 19906867
DOI: 10.1242/dev.039990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.PMID 19906867Read ↗

Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic developmentSemantic proximity Read ↗

Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish.Semantic proximity Read ↗

Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos.Semantic proximity Read ↗

A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.Semantic proximity Read ↗

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental LymphangiogenesisSemantic proximity Read ↗

Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors.Semantic proximity Read ↗

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation.Semantic proximity Read ↗

Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis.Semantic proximity Read ↗

Endothelial Notch signalling limits angiogenesis via control of artery formation.Semantic proximity Read ↗

Development of the Zebrafish Lymphatic System Requires Vegfc SignalingSemantic proximity Read ↗

Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculatureSemantic proximity Read ↗

Arteries provide essential guidance cues for lymphatic endothelial cells in the zebrafish trunkSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.