Development and Characterization of a FRET-based Formin Tension Sensor in Living Cells

Abstract excerpt

Mechanotransduction via the actin cytoskeleton is linked to fundamental cellular processes such as morphogenesis, cell division, and motility, requiring the control of tensile forces mediated by the motor protein non-muscle myosin 2 (NM2). Formins such as mDia1 have been shown to elongate actin structures that are under mechanical tension; conversely, mDia1’s elongation rates are modulated by the applied force. D...

Topics

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• Cell Line, Tumor
• Cell Membrane
• Cellular Senescence
• Electroporation
• Gene Expression Profiling
• Mice
• Single-Cell Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

93e499b8-5f48-50bc-8874-6aa887225a9c

DOI

10.64898/2026.07.11.737992