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From Sensor Design to Force Maps: A Systematic Evaluation of FRET-based Vinculin Tension Sensors

2026-03-25

Abstract excerpt

Mechanical forces transmitted through focal adhesions regulate cell behavior and disease progression, yet remain difficult to quantify at the molecular level. Genetically encoded FRET-based tension probes enable measurements of piconewton-scale forces across specific proteins in living cells, but their quantitative interpretation is highly sensitive to probe design and measurement modality. Here, we systematically...

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Identifiers and source

Literature Corpus work
103a8081-4c65-541f-a5c9-56014818ee8e
DOI
10.64898/2026.03.23.713753
Open publication

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