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Article

High-throughput mechanical phenotyping and transcriptomics of single cells.

Nature communications - 17 May 2024

Shiomi Akifumi, Kaneko Taikopaul, Nishikawa Kaori, Tsuchida Arata, Isoshima Takashi, Sato Mayuko, Toyooka Kiminori, Doi Kentaro, Nishikii Hidekazu, Shintaku Hirofumi

Abstract excerpt

The molecular system regulating cellular mechanical properties remains unexplored at single-cell resolution mainly due to a limited ability to combine mechanophenotyping with unbiased transcriptional screening. Here, we describe an electroporation-based lipid-bilayer assay for cell surface tension and transcriptomics (ELASTomics), a method in which oligonucleotide-labelled macromolecules are imported into cells...

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Identifiers

PMID: 38760380
DOI: 10.1038/s41467-024-48088-5
PMCID: PMC11101642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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