Article

The sodium leak channel complex is modulated by voltage and extracellular calcium

2019-08-20

Abstract excerpt

<h4>Summary</h4> The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations are life-threatening in humans and knockout is lethal in mice. However, the basic functional and pharmacological properties of NALCN have remained elusive. Here, we found that the robust function of NALCN in heterologous systems requires co-expression of UNC79, UNC80 and FAM155A. The resulting NALCN channel comp...

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Literature Corpus work: 7e4c0811-403b-54ed-88a3-c0db8c712f15
DOI: 10.1101/740456

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