Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel.

Molecular brain - 13 Apr 2011

Bouhours Magali, Po Michelle D, Gao Shangbang, Hung Wesley, Li Hang, Georgiou John, Roder John C, Zhen Mei

Abstract excerpt

Gap junctions mediate the electrical coupling and intercellular communication between neighboring cells. Some gap junction proteins, namely connexins and pannexins in vertebrates, and innexins in invertebrates, may also function as hemichannels. A conserved NCA/Dmα1U/NALCN family cation leak channel regulates the excitability and activity of vertebrate and invertebrate neurons. In the present study, we describe a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cysteine

Share to Gap Junctions

Share to Genes, Dominant

Share to Neuromuscular Junction

Share to Organ Specificity

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 21489288
DOI: 10.1186/1756-6606-4-16
PMCID: PMC3102621

Genes

NALCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel.PMID 21489288Read ↗

Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system.Semantic proximity Read ↗

The sodium leak channel NALCN is regulated by neuronal SNARE complex proteinsSemantic proximity Read ↗

The NALCN regulator UNC-80 functions in a subset of interneurons to affect <i>C. elegans</i> avoidance response to the plant hormone methyl salicylateSemantic proximity Read ↗

Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.Semantic proximity Read ↗

The sodium leak channel complex is modulated by voltage and extracellular calciumSemantic proximity Read ↗

Six innexins contribute to electrical coupling of C. elegans body-wall muscle.Semantic proximity Read ↗

UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.Semantic proximity Read ↗

Innexins: members of an evolutionarily conserved family of gap-junction proteins.Semantic proximity Read ↗

Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations.Semantic proximity Read ↗

Low conductance gap junctions mediate specific electrical coupling in body-wall muscle cells of Caenorhabditis elegans.Semantic proximity Read ↗

Novel pharmacological modulation of dystonic phenotypes caused by a gain-of-function mutation in the Na+ leak-current channel.Semantic proximity Read ↗

The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.