Article

Epithelial-stromal cell interactions and ECM mechanics drive the formation of airway-mimetic tubular morphology in lung organoids

2020-12-03

Abstract excerpt

The complex cellular organisation of the human airway tract where interaction between epithelial and stromal lineages and the extracellular matrix (ECM) make it a difficult organ to study in vitro . Current in vitro lung models focus on modelling the lung epithelium such as air-liquid interface (ALI) cultures and bronchospheres, do not model the complex morphology and the cell-ECM interaction seen in vivo . Mod...

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Literature Corpus work: 843a3d7c-7fd5-5ee4-b2f2-6227078145f8
DOI: 10.1101/2020.12.03.408815

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