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Article

Development of a novel air-liquid interface airway tissue equivalent model for in vitro respiratory modeling studies.

Scientific reports - 22 Jun 2023

Leach Timothy, Gandhi Uma, Reeves Kimberly D, Stumpf Kristina, Okuda Kenichi, Marini Frank C, Walker Stephen J, Boucher Richard, Chan Jeannie, Cox Laura A, Atala Anthony, Murphy Sean V

Abstract excerpt

The human airways are complex structures with important interactions between cells, extracellular matrix (ECM) proteins and the biomechanical microenvironment. A robust, well-differentiated in vitro culture system that accurately models these interactions would provide a useful tool for studying normal and pathological airway biology. Here, we report the development and characterization of a physiologically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37349353
DOI: 10.1038/s41598-023-36863-1
PMCID: PMC10287689

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