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Article

Organotypic sinonasal airway culture systems are predictive of the mucociliary phenotype produced by bronchial airway epithelial cells.

Scientific reports - 10 Nov 2022

Delhove Juliette, Alawami Moayed, Macowan Matthew, Lester Susan E, Nguyen Phan T, Jersmann Hubertus P A, Reynolds Paul N, Roscioli Eugene

Abstract excerpt

Differentiated air-liquid interface models are the current standard to assess the mucociliary phenotype using clinically-derived samples in a controlled environment. However, obtaining basal progenitor airway epithelial cells (AEC) from the lungs is invasive and resource-intensive. Hence, we applied a tissue engineering approach to generate organotypic sinonasal AEC (nAEC) epithelia to determine whether they are...

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PMID: 36357550
DOI: 10.1038/s41598-022-23667-y
PMCID: PMC9648462

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