Article

Engineering a 3D Lung Co-culture Platform to Model Epithelial–Fibroblast Interactions in Pulmonary Fibrosis

2026-05-13

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease (ILD) characterized by progressive fibrosis, irreversible loss of lung elasticity, and chronic respiratory failure, with a mean survival of 3–5 years. The disease is believed to result from repeated alveolar epithelial injury that sustains transforming growth factor-beta (TGF-β) signaling, driving fibroblast-to-myofibroblast differentiation a...

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Literature Corpus work: afee8ca4-6d27-5a92-b4be-3339cfe5a5da
DOI: 10.64898/2026.05.07.723587

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