Article

Development of a Novel Air-Liquid Interface Airway Tissue Equivalent Model for In Vitro Respiratory Modeling Studies

2022-09-22

Abstract excerpt

The human airways are complex structures with important interactions between cells, extracellular matrix (ECM) proteins and the biomechanical microenvironment. A robust, well-differentiated in vitro culture system that accurately models these interactions would provide a useful tool for studying normal and pathological airway biology. Here, we report the feasibility and analysis of a physiologically relevant air-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0a8acf39-30ff-5f22-a591-453d26283a78
DOI: 10.1101/2022.09.21.508886

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of a Novel Air-Liquid Interface Airway Tissue Equivalent Model for In Vitro Respiratory Modeling StudiesDOI 10.1101/2022.09.21.508886Read

Development of a novel air-liquid interface airway tissue equivalent model for in vitro respiratory modeling studies.Semantic proximity Read

Dynamic hybrid-hydrogel lung models decouple matrix composition, stiffness, and fibroblast memory to define distinct drivers of fibrotic progressionSemantic proximity Read

Epithelial-stromal cell interactions and ECM mechanics drive the formation of airway-mimetic tubular morphology in lung organoidsSemantic proximity Read

Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosisSemantic proximity Read

Engineering a 3D Lung Co-culture Platform to Model Epithelial–Fibroblast Interactions in Pulmonary FibrosisSemantic proximity Read

The Development of 3D Primary Co-Culture Models of the Human AirwaySemantic proximity Read

The effect of stromal components on the modulation of the phenotype of human bronchial epithelial cells in 3D culture.Semantic proximity Read

Transitional alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung modelsSemantic proximity Read

A novel in vitro tubular model to recapitulate features of distal airways: The bronchioidSemantic proximity Read

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epitheliaSemantic proximity Read

Do Airway Epithelium Air–Liquid Cultures Represent the In Vivo Airway Epithelium Transcriptome?Semantic proximity Read

Transcriptomic Analysis of Air–Liquid Interface Culture in Human Lung Organoids Reveals Regulators of Epithelial DifferentiationSemantic proximity Read